Scleroderma is a kind of rare, progressive, and rheumatoid disease in which the skins of the patients get thick, hard and dry; and sometimes there are some wounds at the extremities. Accumulation of collagens and other fibers involve the face skin, limbs, hand and feet joints, lungs, kidneys, and alimentary canal (especially esophagus) of the patients and make them unable. This disease can be local or general. 


   What are the symptoms of the disease?
   The signs of this disease are usually dermal that cause skin wounds and hardening of the skin. This harness is gradually progressed and then changed color; it is manifested in darkened skin. In this situation, little protruded vessels are formed under skin which is called skin telangiectasia. Gradually, the skin appearance of these people is prolonged and hardened which are in a special form in face skin. Vertical wrinkles around the lips are increased and mouth opening is problematic.